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Tuesday, 17 August 2021

Angry bees produce higher quality venom than calm ones - and that substance could help in the fight against Parkinson's and osteoarthritis, study says

  • Angry' honeybees produce better venom than docile ones, a new study claims
  • There are 99 bee venom proteins, and the more there are, the higher quality it is 
  • 'Angry bees' reacted better to devices that produced a 'minimal shock'
  • Warmer temperatures also resulted in 'lower venom production,' experts said
  • The venom came from domesticated honeybees in southwestern, Australia The sting from a honeybee may not feel like warm apple pie, but new research has revealed that angry bees produce better venom.

    Researchers at Curtin University studied bees at multiple sites across Australia, and identified 99 bee venom proteins. 

    Interestingly, 'angry' bees - which were riled up using a shocking device - were found to produce a richer, more protein-dense bee venom. 

    The team says this venom could help in the fight against Parkinson's and osteoarthritis.

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    'Angry' honeybees produce better venom than docile ones and used to fight against Parkinson's and osteoarthritis, according to a new study

    'Angry' honeybees produce better venom than docile ones and used to fight against Parkinson's and osteoarthritis, according to a new study

    WHAT IS PARKINSON'S? THE INCURABLE DISEASE THAT STRUCK BOXER MUHAMMAD ALI

    Parkinson’s disease affects one in 500 people, including about one million Americans.

    It causes muscle stiffness, slowness of movement, tremors, sleep disturbance, chronic fatigue, an impaired quality of life and can lead to severe disability.

    It is a progressive neurological condition that destroys cells in the part of the brain that controls movement.

    Sufferers are known to have diminished supplies of dopamine because nerve cells that make it have died.

    There is currently no cure and no way of stopping the progression of the disease, but hundreds of scientific trials are underway to try and change that.  

    The disease claimed the life of boxing legend Muhammad Ali in 2016.

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    The so-called 'angry bees,' those that are considered more active, reacted better to the researchers' electrical stimulating devices, created with a glass plate and an electrical pulse system that produced a 'minimal shock' to the bees.

    'A compelling behavioral factor was revealed by the association between docile and active bees,' the study's lead author, Dr Daniela Scaccabarozzi, from Curtin's School of Molecular and Life Sciences, said in a statement

    'Interestingly, we discovered that the 'angry bees' that reacted intensively to our stimulating devices produced a richer, more protein-dense bee venom.' 

    Scaccabarozzi continued: 'The overall quantity of venom released by bees relies on the alarm pheromone secretion that induces other bees to aggressively react by stinging. This may be a result of changes in genetics that can provoke aggression in bees.' 

    The healing properties of bee venom have been known for some time. Some have used it for chronic injuries, due to its enzymes and peptides that can treat inflammation and central nervous system diseases, such as Parkinson's, Alzheimer's and others.

    Approximately 60,000 Americans are diagnosed with Parkinson's each year, with more than 10 million across the world suffering from the disease, according to the Parkinson's Foundation

    Osteoarthritis, conversely, impacts over 32.5 million US adults, according to the Centers for Disease Control and Prevention

    The venom came from domesticated honeybees, Apis Mellifera Ligustica, from 25 hives near Harvey in southwestern, Australia.

    Experts found there are 99 bee venom proteins and the more protein in the venom, the higher quality it is. This graph shows the composition of venom from angry bees

    Experts found there are 99 bee venom proteins and the more protein in the venom, the higher quality it is. This graph shows the composition of venom from angry bees 

    The researchers also found that warmer temperatures resulted in 'lower venom production,' Dr Scaccabarozzi explained.

    'This met our expectation that seasonal factors do cause a change in the protein profile of bee venom. The optimal range for high protein diversity varies from 33 to 36˚C.'  

    The researchers also found that geographic location impacted the composition of the bee venom.

    'Angry bees' reacted better to the researchers' electrical stimulating devices that produced a 'minimal shock' to the bees

    'Angry bees' reacted better to the researchers' electrical stimulating devices that produced a 'minimal shock' to the bees

    In one of the sites, at Byford, Australia, there was a significant difference in bee venom compared to the two colder sites, Chittering and Harvey.

    'This geographical evidence suggests that exogenic site factors definitely warrant further work to enable effective control of product quality and to design cost-effective strategies for BV harvest,' the researchers wrote in the study.

    The price of bee venom can vary widely, ranging from $30 per gram on the low-end to as high as $300 per gram, according to Bee Venom LabThe research was published in June in the scientific journal PLOS One

    The experts say further research is needed to help beekeepers meet the demand for bee venom, which is used for a variety of different use cases, including face creams and therapeutics.

    It has also been used in treating certain conditions, including arthritis and eczema.  

    Bee venom has also been used to treat certain types of cancer, researchers have found

    DECLINING BEE POPULATIONS

    Declines in recent months to honey bee numbers and health caused global concern due to the insects' critical role as a major pollinator.

    Bee health has been closely watched in recent years as nutritional sources available to honey bees have declined and contamination from pesticides has increased.

    In animal model studies, the researchers found that combined exposure to pesticide and poor nutrition decreased bee health.

    Bees use sugar to fuel flights and work inside the nest, but pesticides decrease their hemolymph ('bee blood') sugar levels and therefore cut their energy stores.

    When pesticides are combined with limited food supplies, bees lack the energy to function, causing survival rates to plummet.

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